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Polysaccharides are ubiquitous, generally benign in nature, and compatible with many tissues in biomedical situations, making them appealing candidates or new materials such as therapeutic agents and sensors. Fluorescent labeling can create the ability to sensitively monitor distribution and transport o polysaccharide-based materials, which can or example urther illuminate drug-delivery mechanisms and thereore improve design o delivery systems. Herein, we review uorophore selection and ways o appending polysaccharides, utility o the product uorescent polysaccharides as new smart materials, and their stimulus-responsive nature, with ocus on their biomedical applications as environment-sensitive biosensors, imaging, and as molecular rulers. Further, we discuss the advantages and disadvantages o these methods, and uture prospects or creation and use o these sel-reporting materials.more » « less
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Novo, Diana C.; Gao, Chengzhe; Qi, Qingqing; Mosquera-Giraldo, Laura I.; Spiering, Glenn A.; Moore, Robert B.; Taylor, Lynne S.; Edgar, Kevin J. (, Carbohydrate Polymers)
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